20.440 Analysis of Biological Networks (BE.440)

As taught in: Fall 2004

Diagram showing virus entering a cell.

Viral induction of interferon. (Image courtesy of MIT OpenCourseWare.)

Level:

Graduate

Instructors:

Prof. John Essigmann

Prof. Ram Sasisekharan

Course Features

Course Description

This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work culminates in the preparation of a unique grant application in an area of biological networks.