20.430J / 2.795J / 6.561J / 10.539J / HST.544J Fields, Forces, and Flows in Biological Systems (BE.430J)

As taught in: Fall 2004

Diagram of charge distribution on thrombin.

Glycoprotein Ibα (GpIbα), a receptor on the surface of platelets in the blood, binds to several signaling molecules including thrombin, an enzyme released from damaged tissue that is required for blood clotting. This diagram shows the charge distribution on the surface of thrombin (red is negative, blue is positive). The GpIba receptor is shown in green with the surface rendered transparent. (Image courtesy of Lawrence Berkeley National Laboratory.)

Level:

Graduate

Instructors:

Prof. Douglas Lauffenburger

Prof. Alan Grodzinsky

Course Features

Course Description

This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.